Unlike many other mental illnesses and disorders, there is no medication to treat BPD.

Medication can actually interfere with BPD treatment.

Over-the-counter sleeping medication can sometimes help.

Medication is prescribed in some cases to manage co-existing specific symptoms like depression, anxiety, social phobia, post-traumatic stress disorder, bi-polar disorder, and psychosis/paranoia.

The most problematic symptoms or comorbid conditions are sometimes prescribed drugs such as anti-convulsants (reduce anger & impulsivity), anti-depressants, anxiolytics (reduce anxiety), and anti-psychotics (reduce paranoid or dissociative symptoms).

Selective serotonin reuptake inhibitors and other antidepressants have frequently been prescribed to patients with BPD, but they are only modestly useful.

Randomized controlled trials now suggest that atypical antipsychotics or mood stabilizers may be better choices, however no type of medication is consistently or dramatically effective and some medications make things worse or interfere with self-improvement efforts.

Drugs are also susceptible to side effects, non-compliance, over-use, and overdose.